Early- and late -onset preeclampsia: an old disease, new ideas

Abstract

Significant differences between preeclampsia manifestations before (early-onset) and after 34
weeks (late-onset) raise the possibility that these are two different diseases. This hypothesis
is strengthened based on genetic, epidemiological and placental differences. However, recent
studies show the possibility of temporal continuity between both clinical phenotypes. In this
context antiangiogenic phenomena and their relation with the fetus may be crucial in clarifying
this unanswered question.
Keywords: Early-onset preeclampsia, late-onset preeclampsia, antiangiogenic imbalance