Defining the Ca 125 value to predict optimal cytoreduction in patients with epithelial ovarian cancer

Abstract

Objective: To define the Ca 125 value to predict optimal cytoreduction in patients
with epithelial ovarian cancer. Methods: Observational, analytical and retrospective
study of 52 consecutive patients who had surgical intervention for clinical stage III
and IV epithelial ovarian cancer and who did not receive preoperative chemotherapy.
These patients were attended between January 2014 and December 2018 in the
Gynecology Service of the Carlos Alberto Seguín Escobedo Hospital, Arequipa, Peru.
Sensitivity, specificity, positive and negative predictive value, and the area under the
ROC curve of the most appropriate Ca 125 cutoff point for optimal cytoreduction
were determined. Results: The patients were on average 58 years old, the serous
histologic subtype was the most frequent with 73.1%; clinical stage IIIC corresponded
to 65.4% of cases and optimal cytoreduction was achieved in 61.5% of patients.
The ROC curve reached 78% with Ca 125 of 716.7 U/mL as the best cut-off point
for predicting optimal cytoreduction, with sensitivity of 75%, specificity 75%, positive
predictive value 82.8% and negative predictive value 65.2%. Conclusion: The tumor
marker Ca 125 was useful in the prediction of optimal cytoreduction in patients who
underwent surgery for epithelial ovarian cancer, with the best cut-off point being
716.7 U/mL.