Clomiphene citrate in infertile women with ovulatory dysfunction

Abstract

Retrospective study in Infertility Clinic Loayza Hospital in Lima, between January 1980 and December 1991. They include 56 infertile ovulatory dysfunction treated with clomiphene citrate for a total of 197 cycles. Thirty patients had chronic anovulation or oligo-ovulation, and 26 patients with luteal phase defect, in 83% of the first group of patients it was possible to induce ovulation, pregnancy rate being 29%. Most patients studied had peritoneal tubi factor associated with ovulatory dysfunction, factor associated with a poor prognosis for pregnancy (p <0.001). In 69% of pregnancies, these were achieved during the first three months of treatment, the required dose being 50 to 100 mg / day in 94% of cases. There were no multiple pregnancies and 1.6% of patients presented clinical data cycles of mild ovarian hyperstimulation.