Aneuploidies in older women, what are the actual risks?
DOI:
https://doi.org/10.31403/rpgo.v58i93Abstract
Over the last decades, there has been a clear tendency in couples planning to have children later in life. Better educational and career opportunities and broad availability of contraception have been some of the contributing factors in couples postponing the beginning of a family. Advanced maternal age (AMA) is currently considered the main risk factor for chromosome aneuploidies, but there is no exact number as to the probability of actually producing aneuploid embryos or a mayor reason for this to happen. The object of this review is to address the recent findings and to near down the probability of actually producing aneuploidy embryos in AMA women. Also we will try to elucidate the actual reason as to why this is happening and how it is related to the age of the mother. We hope these findings will help couples that are thinking about starting a family and couples that are starting or thinking about IVF treatment.Downloads
References
Chiang T, Schultz RM, Lampson MA. Meiotic origins of maternal age-related aneuploidy. Biol Reprod. 2012;86(1):1-7.
Hassold T, Hunt P. Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew. Curr Opin Pediatr. 2009;21(6):703–8.
Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2(4):280-91.
Penrose L. The relative effects of paternal and maternal age in mongolism. J Genet. 1933;27:219-24.
Fitzgerald C, Zimon AE, Jones EE. Aging and reproductive potential in women. Yale J Biol Med. 1998;71(5):367–81.
Benzacken B, Martin-Pont B, Bergère M, Hugues JN, Wolf JP, Selva J. Chromosome 21 detection in human oocyte fluorescence in situ hybridization: possible effect of maternal age. J Assist Reprod Genet. 1998;15(3):105-10.
Roberts CG, O'Neill C. Increase in the rate of diploidy with maternal age in unfertilized in-vitro fertilization oocytes. Hum Reprod. 1995;10(8):2139-41.
Hook EB, Cross PK, Jackson L, Pergament E, Brambati B. Maternal age-specific rates of 47,+21 and other cytogenetic abnormalities diagnosed in the first trimester of pregnancy in chorionic villus biopsy specimens: comparison with rates expected from observations at amniocentesis. Am J Hum Genet. 1988;42(6):797–807.
Hook EB, Cross PK, Schreinemachers DM. Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA. 1983;249(15):2034-8.
Kroon B, Harrison K, Martin N, Wong B, Yazdani A. Miscarriage karyotype and its relationship with maternal body mass index, age, and mode of conception. Fertil Steril. 2011;95(5):1827-9.
Munné S, Chen S, Colls P, Garrisi J, Zheng X, Cekleniak N, Lenzi M, Hughes P, Fischer J, Garrisi M, Tomkin G, Cohen J. Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reprod Biomed Online. 2007;14(5):628-34.
Rabinowitz M, Ryan A, Gemelos G, Hill M, Baner J, Cinnioglu C, Banjevic M, Potter D, Petrov DA, Demko Z. Origins and rates of aneuploidy in human blastomeres. Fertil Steril. 2012;97(2):395-401.
Plachot M, Veiga A, Montagut J, de Grouchy J, Calderon G, Lepretre S, Junca AM, Santalo J, Carles E, Mandelbaum J, et al. Are clinical and biological IVF parameters correlated with chromosomal disorders in early life: a multicentric study. Hum Reprod. 1988;3(5):627-35.
Macas E, Floersheim Y, Hotz E, Imthurn B, Keller PJ, Walt H. Ab normal chromosomal arrangements in human oocytes. Hum Reprod. 1990;5(6):703-7.
Angell RR. Aneuploidy in olderwomen. Higher rates of aneuploidy in oocytes from older women. Hum Reprod. 1994;9(7):1199-200.16.
Brambati B. Chorionic villus sampling: a safe and reliable alternative in fetal diagnosis? Res Reprod. 1987;19:1-2.
Hogge WA, Schonberg SA, Golbus MS. Chorionic villus sampling: experience of the first 1000 cases. Am J Obstet Gynecol. 1986;154(6):1249-52.
Nicolaidis P, Petersen MB. Origin and mechanisms of nondisjunction in human autosomal trisomies. Hum Reprod. 1998;13(2):313-9.
Downloads
Published
How to Cite
Issue
Section
License
Esta revista provee acceso libre inmediato a su contenido bajo el principio de que hacer disponible gratuitamente la investigación al publico, lo cual fomenta un mayor intercambio de conocimiento global.
