Endometriosis-associated infertility management
DOI:
https://doi.org/10.31403/rpgo.v58i81Abstract
Clinical decisions in the management of infertility associated with endometriosis are difficult because many clinical decisión points have not been evaluated in randomized clinical trials. Laparoscopy is the gold standard for diagnosis of endometriosis and the decision to perform it should take into consideration factors such as patient´s age, duration of infertility, family history, pelvic pain, pelvic mass on ultrasound. Conservative surgical treatment of endometriosis must be directed to reproductive function recuperation by eliminating implants and reconstruction of the altered pelvic anatomy. Laparoscopic treatment of endometriosis as compared with laparotomy allows short time of hospitalization, faster recovery, smaller incisions. Surgical treatment of endometriosis associated infertility includes ablation of endometriotic implants and adhesions to improve fertility in minimal and mild endometriosis. In cases of endometriomas 4 cm or larger, laparoscopic cystectomy improves fertility compared with drainage and cauterization. Laparoscopic cystectomy must be carefully performed to avoid damage of normal ovarian tissue, preserving ovarian reserve. Superovulation with intrauterine insemination may be offered after laparoscopy, although expectant management is an option for younger women. In vitro fertilization should be offered in cases of severe tuboperitoneal factor, severe male factor, or in cases of failure to other treatments. Among patients with severe endometriosis, 3 to 6 months of GnRH agonists treatment should be considered.Downloads
References
Mahmood TA, Templeton A. Prevalence and genesis of endometriosis. Hum Reprod. 1991;6:544-9.
Ajossa S, Mais V, Guerriero S, , Paoletti AM, Palmas M, Mascia M, Melis GB. The prevalence of endometriosis in premenopausal women undergoing gynaecological surgery. Clin Exp Obstet Gynecol. 1994;21(2):195-7.
Jefferson L, Cerna S, Rechkemmer A. Endometriosis en pacientes con infertilidad. Ginecol Obstet (Perú). 1999;45(2):91-6.
Missmer SA, Hankinson SE, Spiegelman D , Barbieri RL, Marshall LM, Hunter DJ. Incidence of laparoscopically confirmed endometriosis by demographic, antropometric, and lifestyle factors. Am J Epidemiol. 2004;160(8):784-96.
Hoshiai M. Laparoscopy evaluation of the onset and progression of endometriosis. Am J Obstet Gynecol. 1993;59:1015.
Rechkemmer A. Diagnóstico de endometriosis. Reproducción Humana (Perú). 1999;2(2):22-3.
Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms of endometriosis-associated infertility. Fertil Steril. 2008;90(2):247-57.
American Society for Reproductive Medicine. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817-21.
Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609-15.
Adamson GD. Endometriosis classification: an update. Curr Opin Obstet Gynecol. 2011;23(4):213-20.
The Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility. Fertil Steril. 2006;86(Suppl 4):S156-60.
Hughes E, Fedorkow D, Collins J, Vanderkerckhove P. Ovulation suppression for endometriosis (Cochrane Review). En: The Cochrane Library 2004; Issue 3. John Wiley & Sons Ltd, Chichester, UK.
Kennedy S, Bergqvist A, Chapron Ch, Chapron C, D'Hooghe T, et al; ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20(10):2695-704.
Rechkemmer A. Laparoscopía en endometriosis. Rev Per Ginecol Obstet. 2009;55:17-20
Marcoux S, Canadian Collaborative Group on Endometriosis. Laparoscopic Surgery in infertile women with minimal or mild endometriosis. N Engl J Med. 1997;337:217.
Jacobson TZ, Barlow DH, Konickx P , Garry R. Laparoscopic surgery for subfertility associated with endometriosis (Cochrane Review). En: The Cochrane Library, (2004) Issue 3. John Wiley & Sons Ltd, Chichester, UK.
The Society of Obstetricians and Gynaecologists of Canada (SOGC). Clinical Practice Guideline. Endometriosis: Diagnosis and Management. J Obstet Gynaecol Canada. 2010;32(Suppl 2):S19-22.
Chapron C, Vercellini P, Barakat H, Vieira M, Dubuisson JB. Management of ovarian endometriomas. Hum Reprod Update. 2002;8(6):591-7.
Beretta P, Franchi M, Ghezzi F, Busacca M, Zupi E, Bolis P. Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. Fertil Steril. 1998;70(6):1176-80.
Hart R, Hickey M, Maouris P, Buckett W, Garry R. Excisional surgery versus ablative surgery for ovarian endometrioma: a Cochrane Review. Hum Reprod. 2005;20(11):3000-7.
Royal College of Obstetricians and Gynaecologists (RCOG). The investigation and management of endometriosis. Guideline No. 24. Oxford, October 2006 (reviewed in 2010).
Tummon IS, Asher LJ, Martin JS, Tulandi T. Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. Fertil Steril. 1997;68:8-12.
Guzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkamf MP, et al. Efficacy of superovulation and intrauterine insemination in the treatment of infertility. N Engl J Med. 1999;340:177-83-
Deaton JL, Gibson M, Blackmer KM, Nakajima ST, Badger GJ, Brumsted JR. A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. Fertil Steril. 1990;54:1083-8.
Fedele L, Bianchi S, Marchini M, Villa L, Brioschi D, Parazzini F. Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. Fertil Steril. 1992;58:28-31.
Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev. 2006;25(1):CD004635