Premalignant lesions and cervical cancer unrelated to human papillomavirus

Abstract

Cervical cancer is the second most common malignancy in Peruvian women.
The new WHO classification divides cervical epithelial neoplasms according to
the presence or absence of human papillomavirus (HPV) for both squamous and
glandular types. Much has been studied on HPV-related cervical cancer and little in
HPV-negative cervical cancer, which, although representing a minority group, is of
different behavior and worse prognosis. This review represents an overview of this
pathological with emphasis on molecular aspects. Undoubtedly, with the research of
this pathology group and mainly molecular development, more specific treatments
are expected.