Netrina-1 en sangre como biomarcador para la detección del cáncer de endometrio

Osman  Köse; Elif  Köse; Koray  Gök; Mehmet  S. Bostancı; Mehmet  M. Aslan; Irmak  Sezen Gözükara; Orhan  Ünal

doi:10.31403/rpgo.v69i2580

Authors

Osman Köse Asst. Prof. Sakarya University Faculty of Medicine, Department of Gynecological Oncology Sakarya
Elif Köse Assoc. Prof. Sakarya University Faculty of Medicine, Department of Public Health Sakarya
Koray Gök Assoc Prof, Marmara Training and Research Hospital, Clinic of Obstetrics and Gynecology
Mehmet S. Bostancı Prof. Sakarya University Faculty of Medicine, Department of Obstetrics and Gynecology
Mehmet M. Aslan Asst. Prof. Sakarya Training and Research Hospital, Clinic of Obstetrics and Gynecology
Irmak Sezen Gözükara Medical Doctor (MD), Sakarya Training and Research Hospital Clinic of Medical Biochemistry Sakarya
Orhan Ünal Prof. Yeditepe, University Faculty of Medicine, Department of Obstetrics and Gynecology

DOI:

https://doi.org/10.31403/rpgo.v69i2580

Keywords:

Netrin-1, Endometrial neoplasms, carcinoma, Biomarkers, Uterine hemorrhage, Apoptosis

Abstract

Objective: To investigate the relationship of preoperative netrin-1 with important
clinicopathological and prognostic factors and appropriate cut-off levels in patients
with endometrial cancer. Material-Methods: In this prospective, observational
study, the case and control group were selected among patients who applied
to the Gynecological Oncology Clinic. Four mL of venous blood was drawn into a
biochemistry tube from each patient during the preoperative period. Netrin values
in predicting the presence of malignity were analyzed using ROC (receiver operating
characteristics) curve analysis. The cut-off value was calculated according to the
Youden index. Results: In the study, the cut-off value of malignancy according to
the netrin level was determined as 645.50 mg/dL in the ROC analysis (using the
Youden index). The probability of malignancy in individuals with Netrin values above
this cut-off was 78.2% (95% CI 0.680-0.884). The sensitivity of netrin in showing the
probability of malignancy at this cut-off value was 87.5%, and the specificity 63.6%.
Conclusion: Netrin-1 can be a potential biomarker for endometrial cancer detection
and prognosis evaluation.