Study of the hypothalamic-pituitary-ovarian axis, dysfunctional uterine bleeding.

Abstract

We have studied the interplay of hypothalamus-pituitary and ovarian cancer for three months in three cases of young women with dysfunctional uterine bleeding, by radioimmunoassays serial plasma determinations of FSH, LH, estradiol and progesterone. In 2 patients novulatorios cycles were observed even after administration of clomiphene citrate, presenting at least partial failure, LH surge in response to sharp increases, although irregular, estradiol, follicle from additional secretion. In a probable case it was presented spontaneous ovulatory cycle and then induced by clomiphene. In turn, plasma elevations of LH and FSH, found during treatment with clomiphene and subsequent follicular development, indicate that remained intact negative feedback mechanism between estrogen and the gonadotropins. Judging from these findings, it seems that there are changes in the sensitivity of the hypothalamus, from cycle to cycle, dysfunctional uterine bleeding in adolescence